CHEMriya

The Discovery-Ready Resource for Drug Development

CHEMriya is an ultra-large, combinatorial Chemical Space by OTAVA designed and built for efficient hit expansion, hit-to-lead optimization and compound evolution.
As a valuable source for chemically diverse molecules, it can be used to mine for derivatives and analogs with improved pharmacological, physicochemical and drug-like properties to advance your pipeline.
CHEMriya, OTAVA's on-demand Chemical Space, features 55 billion accessible molecules, based on 323 in-house reactions. Several multi-component and ring-closure reactions provide a vast chemical diversity with a broad range of molecular scaffolds. As every Chemical Space is based on in-house knowledge and resources, CHEMriya will further expand the search horizon of infiniSee, allowing you to search in new areas of tangible molecules.

With the March 2025 update, 149 new reactions were added to CHEMriyas chemistry portfolio, adding over 43 billion of novel molecules to the already ultra-large molecule collection.

Traits
  • Fast delivery within 4 to 8 weeks
  • High synthesis success rate up to over 90% for selected projects
  • Beyond Rule of Five capabilities
  • IP-protected selection: Exclusive six-months period on ordered compounds
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CHEMriya

Focus on Beyond Rule of Five Molecules:
Targeting Hard-to-Drug Areas

As the significance of natural products, peptidomimetics, PROTACs, and other biologically relevant yet non-drug-like compounds continues to grow, CHEMriya broadens the molecular hunting grounds. It enables access to compounds designed for challenging drug targets, including those involved in protein-protein interactions, allosteric modulation, and emerging therapeutic areas.

The extended bRo5-focused collection offers compounds with enhanced molecular diversity, allowing for innovative solutions to previously undruggable targets.

Unlock the Full IP Potential for Your Projects with Novel and Unique Compounds

Selection of molecular scaffolds from the CHEMriya Chemical Space.



Discover nnew chemical entities (NCEs) and new molecular entitites (NMEs) not found in public databases!
CHEMriya comes with unmatched chemical diversity based on unique heterocycles to expand the frontiers of drug discovery. Each update aims to increase the coverage of the chemical landscape ensuring faster access to unique, high-quality compounds.

  • Your searches stay secure and confidential: With the ability to screen CHEMriya on your own local hardware, you keep complete control over your data. Your results and searches are never visible to third parties.
  • Exclusive access: Every ordered compounds will be exclusively reserved for you for six months, ensuring a competitive edge in patent applications and IP strategy.
  • Competitive advantage: CHEMriya provides molecules beyond commercially available libraries, pushing your possibilities ahead of others.

Augment and Accelerate Your Research

CHEMriya serves as a powerful resource for mining novel compounds that seamlessly integrate into computational drug discovery workflows.
It provides a rich pool of diverse and synthetically accessible molecules that can be fed into Computer-Aided Drug Design (CADD) approaches, including virtual screening, molecular docking, and machine learning-driven predictions.

The combinatorial nature of CHEMriya ensures coverage of a wide chemical landscape, enabling the identification of promising candidates for challenging drug targets. Crucially, every compound within CHEMriya is not just theoretical but can be ordered and synthesized with high success rates, ensuring a direct path from in silico discovery to experimental validation.
Access with infiniSee

Access with infiniSee

CHEMriya can be conveniently explored using BioSolveIT's Chemical Space navigation platform, infiniSee. Billions of entries can be searched for relevant chemistry within seconds. Various search algorithms are available to identify the best matches for the objectives of a drug discovery project.
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Want to Take It Into the 3D World?

Want to Take It Into the 3D World?

Chemical Space Docking™ also enables structure-based screening of CHEMriya within your target of interest. Executed within our drug design dashboard SeeSAR, molecules forming the most favorable interactions in the binding site can be efficiently mined on standard hardware, and without a connection to the internet.

This allows in-house projects to be streamlined without the involvement of third parties; you will work in a user-friendly environment with full control over your results.
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More details on CHEMriya