Freedom Space (launched by Chemspace) has undergone a significant expansion, now reaching an impressive 142 billion compounds in its latest version 4.0. This update is a substantial leap forward in synthetic accessibility and diverse chemical representation, offering researchers an expanisve resource for drug discovery and hit identification.
Expanding the Reach of Freedom Space
The new Freedom Space 4.0 builds on previous iterations by integrating 40 well-established reaction protocols, including key medicinal chemistry transformations such as amide formation, arylation, reductive amination, urea formation, and Suzuki coupling. This expansion not only increases the number of accessible molecules but also ensures practical feasibility which crucial in early-phase discovery workflows.
Updates in Version 4.0
- Ultra large expansion from 5 billion to 142 billion compounds—covering a broader spectrum of chemical diversity.
- Specialized subsets, including Rule-of-Five (Ro5) compliant and beyond Ro5 (bRo5) compounds, supporting a wide range of drug-like properties.
- 40 advanced reaction protocols, up from 10 in previous iterations, allowing for a greater variety of structurally distinct molecules.
- Machine learning refinement, further enhancing synthetic accessibility and practical usability.
… and much more!
Exploration with BioSolveIT Tools
Freedom Space 4.0 remains fully accessible within BioSolveIT’s computational ecosystem, allowing:
- Ultra-fast Chemical Space exploration through infiniSee, allowing users to efficiently search and identify promising scaffolds.
- Structure-based virtual screening using SeeSAR’s Chemical Space Docking™, enabling a target-centric approach to finding new leads.
This expansion makes Freedom Space one of the most comprehensive and synthetically viable compound collections available today. By combining scale, diversity, and accessibility, Chemspace and BioSolveIT continue to provide researchers with high-quality, synthesis-ready molecular candidates to accelerate the discovery pipeline.
Learn more about Freedom Space 4.0 update here